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KMID : 1094020070240010005
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Journal of Veterinary Clinics
2007 Volume.24 No. 1 p.5 ~ p.9
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Interspecies Scaling of Roxithromycin Pharmacokinetics Across Species
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Lim Jong-Hwan
Park Byung-Kwon
Yun Hyo-In
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Abstract
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The purpose of this study was to examine the allometric analysis of roxithromycin using pharmacokinetic data. The pharmacokinetic parameters used were , mean residence time (MRT), clearance (Cl) and volume of distribution at steady state . Relationships between body weight and the pharmacokinetic parameter were based on the empirical formula , where ’Y’ is , MRT, Cl, or , W the body weight and ’a’ is an allometric coefficient (intercept) that is constant for a given drug. The exponential term, ’b’, is a proportionality constant that describes the relationship between the pharmacokinetic parameter of interest and body weight. As results of the allometric analyses, the logarithms of , MRT, Cl, and were linearly related to the logarithms of body weight. Results of the current analyses could provide information on appropriate doses of roxithromycin for all species.
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KEYWORD
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Roxithromycin, allometric analysis, interspecies, pharmacokinetics
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